Tir is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.

Mechanism of action:

It works to stimulate first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose-dependent manner. Tirz was also shown to delay gastric emptying, lower fasting and  postprandial glucose concentration, decrease food intake, 4 and reduce body weight in patients with type 2 diabetes.

Potential Research Applications

Appetite control and satiety studies

Blood glucose and insulin sensitivity research

Obesity and metabolic syndrome models

GLP-1 receptor pathway modulation investigations

Tir mechanism of action: effects on endocrine function and insulin resistance in patients with type 2 diabetes. Tirpatide is a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP-1) receptor agonist approved in the United States as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes. It is under investigation for use in chronic weight management, major adverse cardiovascular events, and the management of other conditions, including heart failure with preserved ejection fraction, obesity, and non-cirrhotic non-alcoholic steatohepatitis. The Phase 3 SURPASS 1-5 clinical trial programme was designed to assess the efficacy and safety of once-weekly subcutaneously injected tir (5, 10, and 15 mg), as monotherapy or combination therapy, across a broad spectrum of people with type 2 diabetes.

Use of tir in clinical studies was associated with marked reductions in glycated haemoglobin (-1.87 to -2.59%, -20 to -28 mmol/mol) and body weight (-6.2 to -12.9 kg), as well as reductions in parameters commonly associated with heightened cardiometabolic risk such as blood pressure, visceral adiposity, and circulating triglycerides. In SURPASS-2, these reductions were greater than those with the GLP-1 receptor agonist se 1 mg. Tir was well tolerated, with a low risk of hypoglycaemia when used without insulin or insulin secretagogues, and showed a generally similar safety profile to the GLP-1 receptor agonist class. Accordingly, evidence from these clinical trials suggests that tir offers a new opportunity for the effective lowering of glycated haemoglobin and body weight in adults with type 2 diabetes.

Factory Introduction

Analysis Report

Customer Feedback

Factory Introduction

Shanghai Rise & Shine New Materials Co. LTD is a national high-tech enterprise deeply rooted in the biopolypeptide sector, specializing in the R&D, production, sales, and full-chain services of peptide products. We are committed to empowering the health and beauty industries with independent innovative technologies.

Core Positioning and Mission:

We focus on the core biopolypeptide track and build a complete industrial chain from raw material R&D to end-user applications, covering diverse scenarios such as pharmaceuticals, functional foods and health products, and cosmetics.

Adhering to the philosophy of “Independent Technology, Quality First” and with the mission of “Making Biopeptides Benefit More People”, we strive to promote “Chinese Peptides” to the global market.

Quality Control and Market Layout

We strictly implement a comprehensive quality management system: every link, from raw material procurement and production processes to product inspection, is strictly controlled to ensure high quality and stability of products.

Global market presence: Our products are sold to multiple countries and regions, earning wide recognition and trust from customers worldwide.

Adhere to the principle of “Quality First, Customer Foremost”: We center on customer needs, providing personalized product customization and solutions to meet diverse requirements.

If you′re looking for a reliable and effective solution to support your weight management journey, Shanghai Rise & Shine New Materials Co. LTD is your trusted partner. Contact us today to learn more about our products and how they can help you achieve your goals.

FAQ

Q1: What is the ordering process for the product?

A: Please tell us the specific product specifications and quantities you require.Then tell us your delivery information. We will arrange payment for you and ship the goods to you as soon as possible after payment is successful.

Q2: What is the minimum amount I can order?

A: The minimum quantity we can order is 1 box, which contains 10 vials.

Q3: When can I receive the package?

A: It will be shipped as soon as possible after payment, and the shipping time is generally 7 to 15 days.

Q4: Will you supply samples for test the quality?

A:Yes, the shipping cost is borne by customers.